Author: Жураева, Гулбахор Бахшиллаевна; Зикирова, Азиза Ибодиллаевна

Annotation: In this study, the expression level of immunohistochemical marker Ki-67 and the proliferation index were investigated in endometriosis of various organs. A total of 28 cases of endometriosis, 8 cases of cervical canal, 6 cases of myometrium, 7 cases of fallopian tubes and 9 cases of ovarian endometriosis were taken as material. Ki-67 expression and proliferative index were determined by immunohistochemical method. According to the results, the proliferative index of this marker was found to be low in the epithelium and stroma of the myometrium, low in the epithelium of the cervical canal, moderate in the stroma, moderate in the epithelium of the uterine tube, low in the stroma, very high in the epithelium of the ovary, moderate in the stroma. Morphologically, the expression of the Ki-67 marker at different levels in the nucleus of cells and in the karyoplasm and nucleus of the nucleus confirms that the cells are in different phases of proliferative and mitotic activation, i.e. G1, S, G2, M levels. expressed in different ways. If the Ki-67 marker is in the nucleus, it indicates the G1 phase, and if it is located in both the nucleus and the karyoplasm, it indicates the G2 phase.

Keywords: endometriosis, myometrium, cervical canal, uterine tube, ovary, Ki-67 marker.

Pages in journal: 156 - 164