Author: Boboeva, Rano Rakhimovna

Annotation: As a result of the experiment, in acute toxic hepatitis with SsL4 (tetrachloromethane), Rutan polyphenol isolated from the tannin plant Rhus coriaria L. is shown to reduce barbituric sleep due to its effect on drug biotransformation and glucuronidation. These results restore the functional activity of monooxygenase enzyme systems of hepatocytes, which is the basis of the beneficial effect of legalon and rutan on the bile production function of the liver in acute toxic hepatitis.

Keywords: tetrachloromethane, biotransformation, glucuronidation, barbituric sleep

Pages in journal: 679 - 685