Author: Khusainova, Munira Alisherovna; Eshmamatova, Fayyoza Boymamatovna; Ismoilova, Khusnora Tursunboyevna; Mamadiyorova, Mashxura Mashrabovna

Annotation: Rheumatoid arthritis and metabolic syndrome have common pathogenic mechanisms, thereby potentiating each other together, forming a high risk of cardiovascular diseases. The aim of the study was to study the effect of metabolic syndrome on the course of rheumatoid arthritis and the formation of cardiovascular risk. During the study, a clinical evaluation of 100 patients with rheumatoid arthritis, average age 55±12.4 years. The patients were divided into 2 groups depending on the presence of metabolic syndrome: Group 1 – persons with metabolic syndrome (59 people, 59%) and group 2 - persons without metabolic syndrome (41 patients, 41%). The data obtained were processed using the STATISTICA 10 program. Differences in indicators were considered statistically significant at p<0.05. Results and their discussion. In group 1, the activity of rheumatoid arthritis was higher (DAS-28 index was 5.58±0.9) than in group 2 (DAS-28 index was 5.23±0.85) (p=0.02). The daily dose of glucocorticosteroids was higher in the group with metabolic syndrome: in terms of prednisone 7.5 [5; 10] mg versus 5 [5; 10] mg in the group without metabolic syndrome (p=0.013). Verified arterial hypertension was 3.8 times more common in the presence of metabolic syndrome. Left ventricular myocardial hypertrophy was 1.5 times more common in patients in the group with metabolic syndrome (35.9%), and it was noted both in combination with arterial hypertension and without it. In group 1, hypertrophy left ventricular myocardium, unrelated to arterial hypertension, was found in 9 people (9.78%). In group 2, myocardial hypertrophy was associated with arterial hypertension in all patients. The presence of metabolic syndrome in rheumatoid arthritis is associated with a higher activity of rheumatic disease. In patients with rheumatoid arthritis, it contributes to an increase in cardiovascular risk, characterized by a higher incidence of arterial hypertension (3.8 times), an increase in the level of total cholesterol and an increase in the mass of the myocardium of the left ventricle. In patients with a combination of rheumatoid arthritis and metabolic syndrome, myocardial hypertrophy was detected even in the absence of arterial hypertension, which dictates the need for echocardiography in this group of patients.

Keywords: rheumatoid arthritis, metabolic syndrome, cardiovascular risk

Pages in journal: 331 - 339