Author: Khusainova, Munira Alisherovna; Toirov, Doston Rustamovich; Khaydarov, Sanjar Nizamitdinovich; Kamolova, Diyora Djamshedovna

Annotation: The natural cessation of estrogen production occurring during menopausal to the development of endothelial dysfunction and increased thrombosis activity along with a change in the balance of vasoconstrictors/vasodilators. In this connection, the study of the features of morphofunctional heart parameters in women suffering from arterial hypertension that developed during menopause and the therapeutic response to the use of an angiotensin-converting enzyme inhibitor is an urgent research task. With the onset of menopause, the frequency of arterial hypertension (AH) in women significantly increases. In perimenopausal women suffering from menopausal syndrome, the incidence of hypertension increases to 52.4%. This, in turn, increases the risk of coronary heart disease (CHD) by 3 times, and stroke - 7 times. The sex hormones produced throughout the reproductive period of a woman's life, estrogens, have a fairly extensive spectrum of action on the body, but the most important among them is the direct and indirect effect on the cardiovascular system. Direct action is implemented through maintaining balance: endothelium-dependent and endothelium-independent vasodilation. By influencing the cardiomyocyte, estrogens indirectly act on the regulation of the antioxidant and lipid status of the body. In addition, estrogens inhibit the expression of adhesion molecules and platelet aggregation, and also have an antithrombotic effect.

Keywords: arterial hypertension, menopause, morphofunctional parameters of the heart, left ventricular hypertrophy, ACE inhibitors

Pages in journal: 322 - 330