Author: Adilbekova, Dilorom Baxtiyarovna; Xojaniyazova, Aruna Zinatdinovna; Ahrorov, Abdulaziz Azizjonovich; Toshpo‘latov, Sardorjon Sarvarjonovich

Annotation: This article presents a comparative analysis of sex-specific morphological, histological, and morphometric changes observed in the heart tissue of offspring born to mothers with diabetes. During the study, structural differences at the cellular and tissue levels in the walls of the ventricles of males and females were identified, and their responses to the diabetic intrauterine environment were studied. As a result of histological analyses, significant sex differences were noted in the diameter of myocardial fibers, nuclear shape, amount of interstitial connective tissue, and capillary density. Based on morphometric parameters, changes in the thickness of the heart walls and the size of myocardial cells due to the effects of diabetic pregnancy were identified. The data obtained indicate that the effect of diabetes on the heart tissue of offspring is a complex, multifactorial process, and sexual differentiation plays an important role in these changes. The results of the study provide a scientific basis for assessing the impact of metabolic disorders in the prenatal period on heart morphogenesis and for a deeper understanding of the pathogenesis of subsequent cardiometabolic diseases.

Keywords: diabetes mellitus, white laboratory rats, cardiac morphometry, sexual dimorphism.

Pages in journal: 178 - 184