Author: Сахаталиева, Райхона Рафаэлевна; Исроилов, Ражаббой Исроилович; Маматалиев, Авазбек Рузиваевич

Annotation: In this study, the degree of expression of the antiapoptotic protein Bcl-2 at different stages of bladder leukoplakia was determined. The results showed that in the control group, in the urinary bladder epithelium, this protein was found to be less expressed only in the basal layer. In the first I-stage of leukoplakia development, during the onset of the metaplastic process in the variable epithelium, a high level of Bcl-2 protein expression was observed in the cells of the basal layer of the epithelium where acanthosis developed. In stage II of leukoplakia, all epithelial cells are metaplasia and located vertically, their basal and interstitial cells express relatively high levels of Bcl-2 protein, and in stage III of the disease, the expression of this protein is even higher.

Keywords: bladder, cystitis, leukoplakia, immunohistochemistry, Bcl-2 protein.

Pages in journal: 39 - 45